Stem cells: the generation and maintenance of cellular diversity.
نویسندگان
چکیده
Introduction Stem cells in adult self-renewing tissues Haemopoiesis Epidermis Gastrointestinal epithelium General characteristics of stem cells Asymmetric divisions Predetermined asymmetry Yeast C. elegans What are the mechanisms of predetermined asymmetric divisions? Asymmetry without lineage involvement Stochastic events Stem cell heterogeneity Environmental regulation Conclusions What is the difference between two daughter cells that result from an asymmetric division? Unlimited self renewal versus finite transit amplifying divisions The differentiation process is unidirectional Conclusions and prospects
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عنوان ژورنال:
- Development
دوره 106 4 شماره
صفحات -
تاریخ انتشار 1989